The opening ceremony of the 21st Mezipatra took place for the first time in history online on November 5, 2020. It was hosted by the popular hosts of Buchty show (Ivana Veselková and Zuzana Fuksová) from Radio Wave. The evening continued with the premiere of the film No Hard Feelings (Futur Drei), followed by the All for One party in the form of an online DJ set.